Abstract Objectives Components of the hypothalamic-pituitary axis (HPA) pathway are potential mediators of the genetic risk of polycystic ovarian syndrome (PCOS).Impaired glucocorticoid receptor (NR3C1) expression and function may underlie impaired HPA-axis cortisol activity, thereby also contributing to the increased adrenal cortisol and androgen

Most refugees do not leave their home with a national copyright in hand.Nor do they have prepaid tickets for their transport since they do not take national airlines or railways when they leave their countries.They leave in acute situations and for many of them their journey is hampered by acute problems.They flee in disguise, avoid faber grexia gr

The motion of drill strings is modeled in the drilling of geotechnological wells in the mining industry by the Lumped-Parameter Method (LPM).This method is widely used in structural mechanics and is most justified in modeling dynamic systems with a variable structure.On the example of horizontal drilling of geotechnological wells, longitudinal vibr

Historically, cosmopolitan phytoplankton species were presumed to represent largely unstructured populations.However, the recent development of molecular tools to examine genetic diversity have revealed differences in phytoplankton taxa across geographic scales and provided insight into the physiology and ecology of blooms.Here we describe the gene

Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells.However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturbed hematopoiesis and perturbed hematopoiesis.Also,